Abstract

Background: Stem cell donation is crucial for bone marrow transplantation, a lifesaving procedure for various malignant and non-malignant disorders. This process requires recruiting a donor to extract stem cells capable of regenerating healthy cells in recipients. Despite the critical importance of donation, donor’s decision to become a donor can be affected due to so many factors both positively and negatively.  

Purpose: The study aimed to explore perceptions of stem cell donors regarding the donation process at a tertiary care hospital of Islamabad, Pakistan.

Methodology: A qualitative descriptive research design was employed, using convenience and purposive sampling to include ten participants. Data were collected through face-to-face interviews guided by a semi-structured format, which were audio-recorded and transcribed verbatim. The transcriptions underwent manual content analysis for categorization.

Findings: Three categories emerged from the data analysis: “Finding a Silver Lining,” “Moral Imperatives,” and “Physio-Psychosocial Hardships.” Initially, donors exhibited ambivalence and lacked sufficient understanding of the donation process but eventually consented to participate. Key motivating factors included familial bonds, family concerns, and a commitment to assist others. Despite this, donors faced significant practical challenges affecting various aspects of their daily lives.