The Role of high Allostatic Load in the Progression of Type 2 Diabetes

Abstract

 Background:  Diabetes mellitus type 2 is a chronic disease characterized by a metabolism disturbance. An allostatic load measures cumulative wear and tear on the body in response to chronic stress and has been linked to the development and progression of T2DM. Objectives:  This study was to determine the relationship between allostatic load, Dietary pattern, and diabetes. Another purpose was to assess the impact of dietary patterns on allostatic load and diabetes risk. Methods:  A descriptive observational study based on a questionnaire completed by 350 patients aged 30 to 55 diagnosed with type 2 diabetes mellitus was conducted for three months. Anthropometric measurements and laboratory investigations were conducted to assess primary and secondary outcomes. The statistical analysis used the mean ± standard deviation and applied logistic regression analysis to determine the association between different risk factors (allostatic load, nutritional status, BMI, CRP, and total cholesterol) and the outcome of uncontrolled diabetes. Results:  The allostatic load was a significant predictor of uncontrolled diabetes, with a regression coefficient of 0.191 (p = 0.0017) and an odds ratio of 2.19. Nutritional status, BMI, CRP, and total cholesterol were insignificant predictors. The odds ratios for these variables were 0.90, 1.09, 0.70, and 1.93, respectively, with wide confidence intervals that included the possibility of no effect. The chi-square test showed a significant association between diabetes control status and allostatic load (p = 0.0017).