Formulation Development and Evaluation of Mucoadhesive Patch for Diabetes Using Plant Based Polysaccharides

Abstract

Using plant-based polysaccharides, this study created a mucoadhesive patch for diabetes with the goal of delivering regulated medication release and improved therapeutic efficacy through sustained contact with the buccal mucosa. The patches' physicochemical characteristics, drug release kinetics, and mucoadhesive strength were examined after they had been made using the solvent casting procedure. The created patch had exceptional mechanical, flexible, and physical qualities, as well as prolonged drug release and minimized burst release. Through in vitro cytotoxicity tests, the patch's biocompatibility was verified, demonstrating its suitability for buccal administration. To confirm the effectiveness and safety of this unique medication delivery method, additional in vivo research and clinical trials are required. If successful, these studies could pave the way for more individualized and efficient diabetic treatment options.